Jun-Ichi Yamaguchi Selected Research

MGS 0008

10/2020	Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability.
10/2019	Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia.

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Jun-Ichi Yamaguchi Research Topics

Disease

3	Inflammation (Inflammations) 10/2018 - 01/2018
2	Hypoxia (Hypoxemia) 07/2022 - 01/2021
2	Schizophrenia (Dementia Praecox) 10/2020 - 10/2019
2	Coronary Artery Disease (Coronary Atherosclerosis) 07/2015 - 05/2009
1	Sleep Initiation and Maintenance Disorders (Insomnia) 04/2024
1	Drug-Related Side Effects and Adverse Reactions 01/2023
1	Neoplasms (Cancer) 11/2021
1	Treatment-Resistant Depressive Disorder 10/2018
1	Breast Neoplasms (Breast Cancer) 04/2017
1	Liver Failure 01/2016
1	Stroke (Strokes) 07/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 07/2015
1	Hypertension (High Blood Pressure) 05/2009
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2003

Drug/Important Bio-Agent (IBA)

3	Antidepressive Agents (Antidepressants)IBA 10/2018 - 01/2018
2	EstersIBA 01/2023 - 10/2019
2	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 10/2020 - 10/2019
2	MGS 0008IBA 10/2020 - 10/2019
2	Ketamine FDA LinkGeneric 10/2018 - 10/2018
2	candesartanIBA 07/2015 - 05/2009
1	OrexinsIBA 04/2024
1	GlucuronidesIBA 01/2023
1	Prolyl-Hydroxylase InhibitorsIBA 07/2022
1	TP0463518IBA 07/2022
1	troponeIBA 11/2021
1	Amino Acids FDA Link 11/2021
1	Phosphotransferases (Kinase)IBA 11/2021
1	guaiazulene (azulon)IBA 11/2021
1	NucleotidesIBA 11/2021
1	LipidsIBA 11/2021
1	EnzymesIBA 01/2021
1	Cytochrome P-450 CYP1A2 (CYP1A2)IBA 01/2021
1	Cytochrome P-450 CYP3AIBA 01/2021
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2021
1	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 01/2021
1	Glutamic Acid (Glutamate)FDA Link 10/2019
1	ProdrugsIBA 10/2019
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2018
1	norketamineIBA 10/2018
1	LipopolysaccharidesIBA 01/2018
1	Peptides (Polypeptides)IBA 04/2017
1	Organic Anion TransportersIBA 04/2017
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 04/2017
1	1,5- anhydro- 1- (5- (4- ethoxybenzyl)- 2- methoxy- 4- methylphenyl)- 1- thioglucitolIBA 04/2017
1	AnionsIBA 04/2017
1	Proteins (Proteins, Gene)FDA Link 04/2017
1	CationsIBA 04/2017
1	Leucyl Aminopeptidase (Peptidase S)IBA 01/2016
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2016
1	Alkaline PhosphataseIBA 01/2016
1	Alanine Transaminase (SGPT)IBA 01/2016
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 05/2009
1	Angiotensin Receptor AntagonistsIBA 05/2009
1	ameroidIBA 01/2003

Therapy/Procedure

2	Therapeutics 11/2021 - 05/2009
1	Secondary Prevention 07/2015
1	Drug Therapy (Chemotherapy) 05/2009
1	Catheters 01/2003
1	Transplantation 01/2003